ABSTRACT
Non-suicidal self-injury, which is especially common in depressed adolescents, has become an important public health issue of global concern.It’s an independent risk factor for suicide, which not only seriously affects the physical and mental health of individuals, but also brings a great burden to families and society.The research status of non-suicidal self-injury in adolescent depression were systematically evaluated, aiming to improve the understanding of non-suicidal non-suicidal self-injury in adolescent depression, and provide a basis for clinical treatment and prevention of serious suicidal behavior.
ABSTRACT
Objective To explore the correlation between polymorphisms (SNPs) of locus rs2269272 of glial high-affinity glutamate transporter (SLC1A3) gene and suicide attempt among Chinese adolescents.Methods iMLDRTM genotyping technology was used to detect the polymorphism of rs2269272 SLC1A3 gene loci in 55 suicide attempters and 112 healthy controls,and survival analysis was applied to analyze the relationship between allele (T) and the age of suicide attempt.Results The differences of rs2269272 locus allele distribution between two groups were statistically significant(x2=4.208,P=0.040),but genotype distribution of two groups had no significantly differences(x2 =4.011,P=0.135).Non-suicidal self-injury adolescents with locus rs2269272 (15.6 ± 0.4) were younger than adolescents without locus rs2269272(16.4±0.7),but the difference was not statistically significant.Conclusion Preliminary findings suggest that rs2269272 SLC1 A3 may be relevant to non-suicidal self-injury acts,and rs2269272 locus allele is not related to earlier suicide attempt.